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Cimetidine (800 mg), a nonspecific CYP inhibitor, caused a 56% step-up in plasm sildenafil citrate concentrations when co-administered with VIAGRA (50 mg) to intelligent volunteers. In volunteers with liverwort stultification (Child-Pugh Class Aand B), sildenafil citrate headroom was reduced, resulting in higher plasm exposureof sildenafil citrate (47% for C grievous bodily harm and 85% for AUC). The pharmacokinetics ofsildenafil in patients with hard afflicted internal organ part (Child-PughClass C) rich person not been deliberate. A start loony toons of 25 mg should be consideredin patients with whatsoever grade of liverwort handicap [see DOSAGE ANDADMINISTRATION and CLINICAL PHARMACOLOGY].
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