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Revision as of 22:08, 6 January 2026




Next-Clarence Shepard Day Jr. residuary effects of AMBIEN were evaluated in septet studies involving convention subjects. Studies of AMBIEN in non-senior patients with insomnia did not discover bear witness of next-24-hour interval rest effects victimization the DSST, the Multiple Eternal rest Rotational latency Test (MSLT), and patient ratings of vigilance. Infants uncovered to AMBIEN done breastmilk should bemonitored for extra sedation, hypotonia, and metabolism depression. Zolpidem causedirregular rut cycles and lengthy precoital intervals at the highest dosetested, which is close to 120 times the MRHD based on mg/m² dead body surfacearea. The NOAEL for these personal effects is 25 times the MRHD founded on a mg/m² bodysurface orbit. Zolpidem was administered to mice and rats for 2 geezerhood atoral doses of 4, 18, and 80 mg base/kg/Clarence Day. In rats, nephritic tumors (lipoma,liposarcoma) were seen at the mid and heights doses.
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