2024年FDA新药盘点:小分子占据半壁江山,多肽和核酸类药物占比近10% 活性 fda 突破性治疗品种 网易订阅: Revision history

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19 January 2026

  • curprev 11:1811:18, 19 January 2026 NellieFoulds talk contribs 9,438 bytes +9,438 Created page with "<br><br><br>PARP1/2 的激活对于招募 DNA 修复的关键效应子很重要(图4)。 细胞中的 DNA 损伤, 包括单链断裂 (SSB) 跨性别色情片 和双链断裂 (DSB),可通过暴露于化学物质(如化学疗法)、物理试剂(如放射疗法)或内源性反应性代谢物(如活性氧和氮物质)引起(图4)。 SSB 修复的机制包括碱基切除修复、核苷酸切除修复和错配切除修复,而 DSB 修复包括..."